Soigner glaucome avec cellules souches

Bonjour,

Vous souhaitez savoir si le glaucome à angle ouvert peut être soigné par cellules souches.

Nos recherches documentaires semblent indiquer que l’utilisation de cellules souches pour traiter le glaucome ouvert est encore au stade de l’expérimentation. Voici deux articles scientifiques que nous avons repérés en interrogeant Medline (base de données bibliographique multilingue produite par la National Library of Medicine (NLM™) aux Etats-Unis dans tous les domaines biomédicaux) via l’interface Medline.
Vous pouvez si besoin utiliser le traducteur Deepl :  https://www.deepl.com/fr/translator

- A novel glaucoma approach: Stem cell regeneration of the trabecular meshwork / Sara J Coulon, Joel S Schuman, Yiqin Du, Mohammad Reza Bahrani Fard, C Ross Ethier, W Daniel Stamer. – Progress in Retinal and Eye Research (2022 Sep;90:101063)

Abstract
Glaucoma is the leading cause of global irreversible blindness, necessitating research for new, more efficacious treatment options than currently exist. Trabecular meshwork (TM) cells play an important role in the maintenance and function of the aqueous outflow pathway, and studies have found that there is decreased cellularity of the TM in glaucoma. Regeneration of the TM with stem cells has been proposed as a novel therapeutic option by several reports over the last few decades. Stem cells have the capacity for self-renewal and the potential to differentiate into adult functional cells. Several types of stem cells have been investigated in ocular regenerative medicine: tissue specific stem cells, embryonic stem cells, induced pluripotent stem cells, and adult mesenchymal stem cells. These cells have been used in various glaucoma animal models and ex vivo models and have shown success in IOP homeostasis and TM cellularity restoration. They have also demonstrated stability without serious side effects for a significant period of time. Based on current knowledge of TM pathology in glaucoma and existing literature regarding stem cell regeneration of this tissue, we propose a human clinical study as the next step in understanding this potentially revolutionary treatment paradigm. The ability to protect and replace TM cells in glaucomatous eyes could change the field forever.

https://pubmed.ncbi.nlm.nih.gov/35398015/

- Newer advances in medical management of glaucoma / Neethu Mohan, Arup Chakrabarti, Nazneen Nazm, Rajvi Mehta, Deepak P Edward. - Indian Journal of Ophthalmology (2022 Jun;70(6):1920-1930

[…]
The relatively short term effect on IOP, the risks of developing tolerance and side effects impacting patients' neurocognitive health greatly outweigh the potential benefit. Research on Latrunculin B, Adenosine receptor agonists, Specific gene silencing and Stem cell therapy are poised to make an impact on glaucoma treatment. While there is some evidence to support the role of Brimonidine in neuroprotection, further research is needed to clarify the role of Memantine and Neurotrophins. Evidence for benefit from dietary supplementation with Alpha lipoic acid, Forskolin , and Ginko Biloba is limited.

https://pubmed.ncbi.nlm.nih.gov/35647957/

Nous espérons que ces informations vous seront utiles et restons à votre disposition pour toute recherche documentaire dans le domaine de la santé.

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